Risheng Xu, M.D., Ph.D., A.M.

Headshot of Risheng Xu
  • Assistant Director, Neurosurgery Residency Program
  • Assistant Professor of Neurosurgery

Languages: English, Chinese


Acoustic Neuromas, Arteriovenous Malformations (AVM), Cerebral Aneurysms, CyberKnife and Stereotactic Radiosurgery, Dural Arteriovenous Fistulas, Intracerebral Hemorrhage, Moyamoya Disease, Neurosurgery, Skull Base Tumors, Stereotactic Radiosurgery, Subarachnoid Hemorrhage, Trigeminal Neuralgia ...read more

Research Interests

neuroinflammation after ischemic stroke and molecular mechanisms underlying trigeminal neuralgia ...read more

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The Johns Hopkins Hospital

Appointment Phone: 410-955-6406
600 N. Wolfe Street
Baltimore, MD 21287 map
Fax: 443-287-5298

Johns Hopkins Bayview Medical Center

Appointment Phone: 410-955-6406
4940 Eastern Avenue
Baltimore, MD 21224 map
Fax: 443-287-5298


Risheng Xu, M.D., Ph.D., is a fellowship-trained neurosurgeon with expertise in cerebrovascular and endovascular neurosurgery, and skull base pathologies. He treats patients with a wide range of cerebrovascular disorders such as cerebral aneurysms, subarachnoid hemorrhage, arteriovenous malformations, arteriovenous fistulas, carotid stenosis, cavernous malformations and moyamoya disease. He also treats skull base tumors such as acoustic neuromas (vestibular schwannomas) and meningiomas, and pain disorders such as trigeminal neuralgia.

Dr. Xu completed his undergraduate studies at Harvard College, and attended medical school at the Johns Hopkins University School of Medicine, where he also obtained a Ph.D. in pharmacology and molecular sciences. He continued his residency training in neurosurgery at Johns Hopkins, and remained there to complete a fellowship in cerebrovascular and endovascular neurosurgery. 

Dr. Xu has been active in research throughout his training and has authored and co-authored numerous published studies. His basic science research endeavors focus on neuroinflammation after ischemic stroke and molecular mechanisms underlying trigeminal neuralgia. He has authored or co-authored over 100 manuscripts, and has published in journals such as Nature, Nature Communications, Science Advances, Science Signaling, Neuron, the Proceedings of the National Academy of Sciences (PNAS), the Journal of Neurosurgery, Neurosurgery and other journals. Clinically, he studies the long-term outcomes of patients with cerebrovascular disorders and trigeminal neuralgia. 


...read more


  • Assistant Director, Neurosurgery Residency Program
  • Assistant Professor of Neurosurgery

Departments / Divisions

Centers & Institutes



  • MD PhD; Johns Hopkins University School of Medicine (2015)


  • Neurological Surgery; Johns Hopkins University School of Medicine (2022)

Research & Publications

Selected Publications

Risheng Xu, Sumil K Nair, Joshua Materi, Divyaansh Raj, Giho Park, Ravi Medikonda, Safwan Alomari, Timothy Kim, Yuanxuan Xia, Judy Huang, Michael Lim, Chetan Bettegowda, Safety and cost savings associated with reduced inpatient hospitalization for microvascular decompression World Neurosurgery, 2022 Jul 13; S1878-8750(22)00984-6

Risheng Xu, Joshua Materi, Divyaansh Raj, Safwan Alomari, Yuanxuan Xia, Sumil K Nair, Pavan P Shah, Nivedha Kannapadi, Timothy Kim, Judy Huang, Chetan Bettegowda, Michael Lim, Internal neurolysis versus intraoperative glycerin rhizotomy for trigeminal neuralgia Journal of Neurosurgery 2022 May 6;1-6

Risheng Xu, Michael E Xie, James Feghali, Wuyang Yang, Jennifer Kim, Ryan Lee, Jason Liew, Rafael J Tamargo, Judy Huang Revascularization of Hemorrhagic Moyamoya Disease in a North American Cohort: The Role of Timing in Perioperative and Long-Term Outcomes Neurosurgery 2022 Apr 1;90(4):434-440

Risheng Xu, Michael E Xie, Wuyang Yang, Philippe Gailloud, Justin M Caplan, Christopher M Jackson, Eric M Jackson, Mari L Groves, Shenandoah Robinson, Alan R Cohen, Judy Huang, Rafael J Tamargo Epidemiology and outcomes of pediatric intracranial aneurysms: comparison with an adult population in a 30-year, prospective database Journal of Neurosurgery Pediatrics 2021 Sep 10;1-10

Bindu D Paul, Juan I Sbodio, Risheng Xu, M Scott Vandiver, Jiyoung Y Cha, Adele M Snowman, Solomon H Snyder Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington's disease Nature 2014 May 1;509(7498):96-100


Treatment of Drug Abuse by Preventing GAPDH Nitrosylation
Patent # P12097 | 

Activities & Honors


  • Harvey Cushing Hunterian Research Award, 2022
  • Frank L. Coulson, Jr. Award for Clinical Excellence, 2022
  • William H. Sweet Young Investigator’s award by the American Association of Neurological Surgeons, 2022
  • Irving J. Sherman Award for Resident Achievement, 2017
  • Election to the Alpha Omega Alpha Honor Medical Society, 2015
  • Johns Hopkins School of Medicine Thomas J. Kelly and Mary L. Kelly Young Scholar Award, 2008
  • Johns Hopkins School of Medicine Franklin Paine Mall Award, 2009
  • Paul and Daisy Soros Fellowship, 2009 - 2011

Videos & Media

Recent News Articles and Media Coverage

Landwehr, Julie. “Why Emilia Clarke's Recovery After 2 Brain Aneurysms Is So 'Remarkable': 'I Am in the Really Small Minority.'” Health, 19 July 2022

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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